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The Joshua Lederberg Papers

Letter from Roger Y. Stanier to Joshua Lederberg pdf (78,238 Bytes) transcript of pdf
Letter from Roger Y. Stanier to Joshua Lederberg
Item is handwritten.
Number of Image Pages:
1 (78,238 Bytes)
1952-10-22 (October 22, 1952)
Stanier, Roger Y.
Lederberg, Joshua
Courtesy of Joshua Lederberg.
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Lederberg Grouping: Correspondence B
Box Number: 8
Folder Number: 64
Unique Identifier:
Accession Number:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence, 1935-2002
SubSeries: 1947-1953
Folder: Stanier, Roger Y.
Oct. 22, 1952
Dear Joshua -
I'm spending my 26th birthday nursing a stinking cold at home, which provides a good opportunity for catching up on correspondence.
Sey Pomper (who is here for a year on a post-doctoral fellowship) has started to work with the purples, assisted by Martha. I'm so overwhelmed with teaching and other academic scut-work that I don't expect to do much myself until after Christmas. It turns out that the Rhodospiriillium rubrum is not too easy to handle. It doesn't grow happily on a streaked[?] plate, and the best method for counts[?] a single colony isolations appears to be incorporation of the moisture[?] in an agar overlayer[?], which presumably gives some protection from high O2 concentrations, as well as the necessary moisture. Growth is relatively slow under the best conditions yet devised ; it takes approx. 4 days to get easily visible colonies in illuminated plates. We don't know whether this reflects long lags or long generation times, but it is clear that adaptation to dark growth requires very different periods[?] with different strains. There may be selective factors at work in this case, of course. Since we have to work out the details of cultivation and general physiology in any case, I suggest that you defer genetic studies until we can let you know a bit more about optimal conditions and about suitable strains (the strain differences appear to be considerable). Sey has run a few expts with streptomycin, but appears to have succeeded only in making the organism highly resistant: single colonies are still well pigmented.
Many thanks for the fine picture of Lot[?]
Best wishes to you both,
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