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The Joshua Lederberg Papers

Letter from Roger Y. Stanier to Joshua and Esther Lederberg Annotation pdf (90,864 Bytes) transcript of pdf
Letter from Roger Y. Stanier to Joshua and Esther Lederberg
Item is handwritten.
Number of Image Pages:
2 (90,864 Bytes)
1952-12-20 (December 20, 1952)
Stanier, Roger Y.
Lederberg, Esther
Lederberg, Joshua
Courtesy of Joshua Lederberg.
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Lederberg Grouping: Correspondence B
Box Number: 8
Folder Number: 64
Unique Identifier:
Accession Number:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence, 1935-2002
SubSeries: 1947-1953
Folder: Stanier, Roger Y.
Dec. 20, 1952
Dear Joshua and Esther -
This emblem of paper superstition is a very inappropriate carrier of Christmas wishes, but it was the only esthetically tolerable card I could find on a frantic last-minute hunt.
No scientific news to speak of. The purple bacterial turn out to be stinkers from the standpoint of growth studies under defined conditions, and so for the only interesting leads are biochemical ones. I think Rhodopseudomonas spheroides[?] may be better than the rest for genetic and physiological studies, as it's much more oxygen tolerant. But very odd things go on when the bugs shift from light to dark metabolism or vice versa, which I don't understand yet, and so far as we haven't got very good growth in a defined medium. We'll notify you when the outlook improves.
How right you were about the tetracolum granula! Weibull has shown conclusively that the "mitochondria" demonstrated with tetrazolin are pure Artifacts[?] : continuous observation reveals that formazon starts to appear as many very small granules, which suddenly coalesce to give the single-granula picture ; furthermore, if he Raytheon[?] stained cells and spins out the formazon, nearly all the reductive power stays behind in the supermutants. If bacterial mitochondria there be, they are probably submicroscopic, like the chromatosphores in purples. Note to Mudd and Delamater. Salton is also active here cytologicallym, doing very pretty work in his cell walls.
Mike is well and very happily married - also doing more research than he has for years, hard in pursuit of that will-o-the-wisps, "permeability."
Hope to see you both this summer. Regards to Quin.
As ever, Roger
P.S. How did you fall down so badly[?] in McCarthy.
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Annotation by Joshua Lederberg:
KW: purple bacteria; difficulties in culture and defined media;
Rhodopseudomonas spheroides may be preferred for genetic studies;
formazan (tetrazolium) granules are not bacterial mitochondria,
contra DeLamater, Mudd; Salton; Weibull; Mike [Doudoroff];
Quin [Luttinger]; [Joe] McCarthy; - probably refers to election;

jl 2/26/99