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The Joshua Lederberg Papers

Letter from Jean Weigle to Joshua Lederberg pdf (54,268 Bytes) transcript of pdf
Letter from Jean Weigle to Joshua Lederberg
Item is handwritten.
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1 (54,268 Bytes)
1957-01-02 (January 2, 1957)
Weigle, Jean
Lederberg, Joshua
Courtesy of Joshua Lederberg.
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Lederberg Grouping: Correspondence C
Box Number: 14
Folder Number: 139
Unique Identifier:
Accession Number:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence, 1935-2002
SubSeries: 1953-1960
Folder: Weigle, Jean
Puerto Vallarta
January 2nd, 1957.
Dear Dr. Lederberg
If you agree with me on the value (?) of the MS I sent to you I think that the next thing, for me, to do is to look into the fact that lambda HFT (from the 112 Gal- transduced cell) does not multiply in a GaI- cell. I would like to prove that lambda HFT multiples in a Gal+ cell and does not multiply as HFT in Gal- cell, not picking[?] the Gal- marker of the host cell (I have prelimaniry [sic] experiments with a bad Gal- of Bollman[?] that seems to show that) or picking it and becoming a new HFT.
For these experiments I would need then your Gal1- and Gal2- strains sensition[?] to lambda (I think the other nutritional markers dont [sic] matter unless you tell me why) and just in case Gal1- and Gal2-. If I need to make them lysogenic I would prefer to have markers (+++) (according to Dale Rainer[?]) on the prophages.
So I would be very grateful to you if you could send me these three strains in Pasadena where I expect to be back in a week or so.
Thanks in advance
Yours Weigli
P.S. Arbor tells me that after transduction with lambda HFT inactivated by UV most (if not all) of the transduced cells are stable Gal+ (and thus not heterogenates). Did Morse find the same thing?
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