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The Joshua Lederberg Papers

Title:
Letter from Aaron Novick to Joshua Lederberg pdf (107,128 Bytes) transcript of pdf
Letter from Aaron Novick to Joshua Lederberg
Description:
Item is handwritten.
Number of Image Pages:
2 (107,128 Bytes)
Date:
1971-09-20 (September 20, 1971)
Creator:
Novick, Aaron
Recipient:
Lederberg, Joshua
Rights:
Reproduced with permission of Aaron Novick.
Relation:
Lederberg Grouping: Correspondence D
Box Number: 23
Folder Number: 48
Unique Identifier:
BBAFXN
Accession Number:
8
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1935-2002
SubSeries: 1961-1978
Folder: Novick, Aaron
Transcript:
20 Sept 71
Dear Josh,
I often have wondered about further studies of anti-mutagenic effects but have not done anything for the following reasons. Chances are pretty good that the effect we studied is on the "repair" system, since it works so well against caffeine mutagenesis, which appears to be on repair. So any meaningful study would quickly become one of the repair system--which would likely be specific to Coli.
But maybe careful study of mammalian repair systems would give direction toward substances which would reduce spontaneous rate in humans.
Another thought--perhaps reducing the rate for one kind of mutational event would increase the rate for another.
One other reason I have shied away is that so much nice work is being done--or should be done--on the molecular basis of mutational events. George Streisinger[?] has some interesting information on the
[END PAGE ONE]
[BEGIN PAGE TWO]
relation between frame shift rate and length of a series of repeating base pairs.
While I have your attention I want to show you the enclosed announcement from the NIH which outraged me.
When will you come up for a visit? Better make it before the California conquest turns this into LA-land.
Nice talking to you,
Aaron
P.S. I found your Forward stimulating
Metadata Last Modified Date:
2011-07-27
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