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The Joshua Lederberg Papers

Title:
Letter from Joshua Lederberg to Max Zelle pdf (62,874 Bytes) transcript of pdf
Letter from Joshua Lederberg to Max Zelle
Number of Image Pages:
1 (62,874 Bytes)
Date:
1949-03-10 (March 10, 1949)
Creator:
Lederberg, Joshua
Recipient:
Zelle, Max
Rights:
This item is in the public domain. It may be used without permission.
Relation:
Lederberg Grouping: Correspondence B
Box Number: 8
Folder Number: 139
Unique Identifier:
BBAGIU
Accession Number:
8
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1935-2002
SubSeries: 1947-1953
Folder: Zelle, Max
Transcript:
March 10, 1949.
Dear Max:
I've managed to develop a heterozygote culture suitable for detailed crossing-over studies sooner than anticipated, and am enclosing H-168. This culture has all the advantages of H-72, plus a few additional markers, so there would be no reason why it should not displace H-72 entirely. It was obtained as Lacv from the cross
B-M- Vlrc Het x T-L-B1- Lac1- Mal- Xyl- Gal- Arab- Mtl- V1r
It is definitely segregating for Lac, Mal, Xyl and Gal, but seems to be pure (hemizygous or homozygous?) for Mal-, Arab-. The "-" in reference to Galactose and arabinose means only somewhat slower than wild type; for lactose, maltose, xylose and mannitol there is a very clear differentiation. I'm checking to verify the heterozygosity of the other loci, but from other experience, Vlc, V1, M, T, and L should be heterozyous also, although with the possible exception of phage resistance (using T5 to score V1r/V1s) these factors are more troublesome to score on large numbers of segregants.
My apologies for the mathematics in my last letter--I just ran across your thesis in J.I.D. I would appreciate a set of your reprints on bacterial variation if you can spare them.
Sincerely,
Joshua Lederberg
Metadata Last Modified Date:
2008-06-04
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