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The Joshua Lederberg Papers

Title:
Letter from Joshua Lederberg to Max Zelle pdf (62,996 Bytes) transcript of pdf
Letter from Joshua Lederberg to Max Zelle
Number of Image Pages:
1 (62,996 Bytes)
Date:
1949-07-29 (July 29, 1949)
Creator:
Lederberg, Joshua
Recipient:
Zelle, Max
Rights:
This item is in the public domain. It may be used without permission.
Relation:
Lederberg Grouping: Correspondence B
Box Number: 8
Folder Number: 139
Unique Identifier:
BBAGJJ
Accession Number:
8
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1935-2002
SubSeries: 1947-1953
Folder: Zelle, Max
Transcript:
July 29, 1949.
Dear Max:
H-168, Lacv.Xylv.Mtlv. etc., has been recovered from the cultures you lately sent, and by now you must have received a copy which has been mailed to you. We tried to reproduce the loss of Xyl+, but in several hundred tests, every Mtlv has been Xylv. The presumption of a second crossing seems to be most likely, but unprovable. I wonder how much of the work on H168 depended on the persistence of the Xyl-? As I have lately been trying to think about it, your single-cell work was directed as answering several questions: a) that single cells so segregate, certainly proven beyond doubt. B) whether the aberrant ratios could be explained by lethals -- very likely, but not directly provable because (probably) of multinucleous cells. C) whether there are two or four strands, and whether segregation occurs in one or two divisions -- the answer to this is a little uncertain, because the previous heterozygotes had one type of segregant so predominant. H-206 should be a superior stock for answering this question, because the 3 classes which do occur are so nearly equal in frequency. I can't yet answer your question about H-206; if you are having trouble reisolating it, let me know and I'll send you another stock. I don't know what else it is heterozygous for.
If you've gotten back to work, let's discuss what's next.
Sincerely,
Metadata Last Modified Date:
2009-06-16
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