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The Joshua Lederberg Papers

Title:
Letter from Joshua Lederberg to Harold Deutsch Annotation pdf (104,139 Bytes) transcript of pdf
Letter from Joshua Lederberg to Harold Deutsch
Description:
Reply from Deutsch is handwritten on bottom of page.
Item is handwritten.
Number of Image Pages:
2 (104,139 Bytes)
Date:
1958-10 (October 1958)
Creator:
Lederberg, Joshua
Recipient:
Deutsch, Harold
Rights:
This item is in the public domain. It may be used without permission.
Relation:
Lederberg Grouping: Correspondence C
Box Number: 9
Folder Number: 195
Unique Identifier:
BBAHOR
Accession Number:
13
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1935-2002
SubSeries: 1953-1960
Folder: Deutsch, Harold
Transcript:
[BEGIN TYPEWRITTEN SECTION]
Dear Harold:
I've just received a reprint from Fred Karush which is very pertinent to the discussion we had at lunch the other day. Fred has done this experiment of reversable [sic] denaturation by the use of high concentrations of urea. While he won't immediately admit this it seems to me that his finding that reversable [sic] denaturation can result in a virtual complete restoration of antibody activity strongly supports the idea of differentiation of antibodies on the basis of amino acid sequence. I am enclosing a thermofax of the relevant page or two which is taken from something called "Serological and Biochemical Comparison of Proteins--14th Annual Protein Conference". I would be very pleased to have you reactions on this.
Joshua
[END TYPEWRITTEN SECTION]
[BEGIN HANDWRITTENS SECTION]
Dear Josh:
First, heartiest congratulations for your well-deserved honor.
The experiments of Karush, while interesting, are not too conclusive of a refolding to a former antibody site structure. Although urea will induce marked structural changes in the secondary structure of the protein, these may have nothing to do with antibody finding activity changes noted. I'm wondering whether similar effects would not be manifested by equal osmotic concentrations of other reagents like NaCl[?],
[END PAGE ONE]
[BEGIN PAGE TWO]
amino acids, sugars, etc. which would not severely affect the secondary structure in a degree similar to that occassioned [sic] by urea.
"An interesting experiment but one capable of variable interpretation". I'd be happy to discuss this further with you sometime.
Harold
Metadata Last Modified Date:
2011-08-04
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Annotation by Joshua Lederberg:
KW:  Karush experiment;
see Karush correspondence; cf P-80;

12/18/99