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The Joshua Lederberg Papers

Letter from P. R. Edwards to Joshua Lederberg pdf (104,089 Bytes) transcript of pdf
Letter from P. R. Edwards to Joshua Lederberg
Item is handwritten.
Number of Image Pages:
2 (104,089 Bytes)
1961-02-01 (February 1, 1961)
Edwards, P. R.
Lederberg, Joshua
This item is in the public domain. It may be used without permission.
Lederberg Grouping: Correspondence D
Box Number: 17
Folder Number: 160
Unique Identifier:
Accession Number:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence, 1935-2002
SubSeries: 1961-1978
Folder: Edwards, P. R.
Feb 1, 1961
Dear Joshua -- Many thanks for your note of 1/23/61 and LT2 and LT22 which arrived safely. It was very stupid of me to have misplaced these cultures and all our l,w transductant. At this late date I've given up hope of finding them. I hope this is our last move. Each succeeding one seems more different. Just old age catching up with me, I suppose.
It was quite a coincidence that I met the Lanni's the very day your letter arrived. They were being shown around the laboratories by one of the CEC[?] staff. They seem very nice and very cordial. I hope we can impose on them for a little advice in the future.
As to our present work, we are faced with the following anomalous serotypes:
1,3,19: q, s, t <-- Z27
qst <-- Z43
qst <-- Z45
q,s,t <-- Z46
3,10: q,s,t <-- Z43
qst <-- Z45
4,12,27: qst <-- Z43
1,13,23,37 Z29 <-- Z37
d <-- Z37
Z4Z23 <-- Z37
Z4Z23 <-- Z45
!! Z <--> l,w <-- Z43
3,15: q,s,t <--Z45
!! e,h <--> 1,2 <--> Z27
Arrows indicate direction of variation which can be accomplished with[?] sera
Most of these variables also have been observed to occur spontaneously.
You can see that these forms pose an intriguing problem. Ive [sic] intended to attack it thru transductions but thus far have had no luck. Z27, Z37, Z43, Z45, and Z46 apparently are not ordinary phase 2 antigens and all this "one directional" variation is something new.
Young Douglas (a med[?] office assigned to us) has worked faithfully at it and is a little discouraged. I thought I'd let him take a fling at some easy transductions with PLT22 to prove to himself that transduction was not just a figment of the imagination.
I hope to be able to talk to you about the monsters outlined above and perhaps dig some new ideas out of you.
With kindest regards to you and Esther,
As ever
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