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The Joshua Lederberg Papers

Title:
Letter from P. R. Edwards to Joshua Lederberg pdf (194,656 Bytes) transcript of pdf
Letter from P. R. Edwards to Joshua Lederberg
Description:
Item is handwritten.
Number of Image Pages:
2 (194,656 Bytes)
Date:
1962-06-06 (June 6, 1962)
Creator:
Edwards, P. R.
Recipient:
Lederberg, Joshua
Rights:
This item is in the public domain. It may be used without permission.
Relation:
Lederberg Grouping: Correspondence D
Box Number: 17
Folder Number: 160
Unique Identifier:
BBAIFV
Accession Number:
13
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1935-2002
SubSeries: 1961-1978
Folder: Edwards, P. R.
Transcript:
June 6, 1962
My dear Joshua -- Recently I received from Simo[?] several reprints and among them was one of yours on alternative phase 1 loci (or duplicate phase 1 loci) which interested me very much. It was most unfortunate that the strains involved had such low phase variation rates since this no doubt hampers the work.
Intermittently for about 2 years I worked on some cultures of S. [ . . . ] which had 4 reversible H phases (6,7:y:Z47:Z50:l,n,Z15). These behaved as diploids(?) and segregated triphasic and diphasic forms in which e,u,Z15 was constantly present, i.e., one obtained stabilized forms such as 6,7: y, Z47: e,u /6,7:y:Z50:e,u/ 6,7:y:eu/ 6,7:Z47:eu/ or 6,7:Z50:e,u. After reading your paper I felt very strongly that we were dealing with a triplication of the phase 1 locus.
I've had the idea that these strains were recombinants and have wanted to do some antigenic work on recombination but this now is out of the question unless I can get a good boy to do it. After resisting for some years I finally broke down and took over the job as chief of the Bacteriology Section so I'm afraid my days of working in the laboratory are finished. In talking with Les Baron recently I gained the idea that antigenic recombination was a tough nut to crack but with proper systems of selection and known Ft strains I do not see why it couldn't be accomplished.
[END PAGE ONE]
[BEGIN PAGE TWO]
I wish you would put some of your people on this problem since we probably will never get to it.
Also complex phases like Z29, e,h: Z29,1,2/Z49r: Z49,1,5/Z45e,h:Z45:L,w pose a distinct problem. We've done some unsuccessful transduction experiments with these .
Kindest regards,
Phil
Metadata Last Modified Date:
2011-08-08
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