The National Library of Medicine's Profiles in Science
program has made every effort to secure proper permissions
for posting items on the web site. In this instance, however,
it has either not been possible to identify or contact the
current copyright owner.
If you have information regarding the copyright owner,
please contact us at
I believe we are both making contributions to the Symposium on Physiological Genetics at the Congress in Montreal. If you
have thought about your paper yet I thought perhaps you could let me have some idea of the ground you intend to cover so that
we can avoid too much of an overlap.
My provisionel [sic] title is "The function of Chromosome loci in enzyme formation", and I was thinking of including
the following: (a) a brief review of cases where auxotrophic mutants can be shown to be defective in a single enzyme, particularly
cases where the mutation seems to have caused a qualitative alteration in the enzyme molecule; (b) evidence for the generalization
(which I think works fairly well on the whole) that all mutations affecting a specific enzyme fall within the same locus,
complex locus or short chromosome segment; (c) relationships between different mutants affecting the same enzyme, including
cases of separability by crossing-over, cases of "Mary Mitchell effect", and cases of partial or complete complementarity
in heterocampons (of which there are at least 3 more); (d) some discussion of different ways of defining chromosome segments,
with the suggestion that perhaps the most important kind of segmentation within the chromosome is the segmentation into "one
enzyme" regions and that these regions are not necessarily either recons or even cistrons. Where possible, of course,
I shall be referring to my own work. Now I have written all this out I can see I may have to cut it down a bit. I think
the most probable area of overlap
[END PAGE ONE]
[BEGIN PAGE TWO]
may be (d) above -- no doubt Lewis will be talking about this too -- so I would be glad to know what you intend to cover.
The expression of different points of view on the same thing may add to the interest, but maybe we should avoid repetition
I have an idea you may not be at Wisconsin any more, but I hope this reached you eventually.