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The Joshua Lederberg Papers

Letter from Joshua Lederberg to Sol H. Goodgal pdf (61,979 Bytes) transcript of pdf
Letter from Joshua Lederberg to Sol H. Goodgal
Number of Image Pages:
1 (61,979 Bytes)
1958-04-25 (April 25, 1958)
Lederberg, Joshua
Goodgal, Sol H.
This item is in the public domain. It may be used without permission.
Lederberg Grouping: Correspondence C
Box Number: 10
Folder Number: 132
Unique Identifier:
Accession Number:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence, 1935-2002
SubSeries: 1953-1960
Folder: Goodgal, Sol H.
April 25, 1958
Dear Sol:
Thanks for your letter and the trouble you're taking to put us on the right track. I was of course very sorry to hear about WH-8, as we had put a fair amount of time in on this culture. I suppose the blame for contamination rests on a god-awful medium like Levinthal's.
I will pick up the air parcel per your indications. We can stick it into the freezer promptly until we are tooled to use the contents.
A propos the role of serum and DPN, we tried some experiments on the availability of DPN for the adenine requirements of an adenineless E. coli. It did not replace adenine, nor did bovine serum, but the mixture did. I would attribute this to an enzyme in the serum which acts as a nucleotidase. As it is no more (nor less) likely that DPN permeates Hemophilus as such, there may be a comparable function of serum. If so, Hemophilus should be more readily grown in the absence of serum if it is furnished nicotinic riboside in place of DPN.
I will still wait for the outcome of your --x experiments with WH-8 Sr; there might be a very remote chance that this is still a mutant of Hemophilus, though this is stretching expectations a good deal.
Yours sincerely,
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