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The Joshua Lederberg Papers

Title:
Letter from Herman M. Kalckar to Joshua Lederberg pdf (105,220 Bytes) transcript of pdf
Letter from Herman M. Kalckar to Joshua Lederberg
Description:
Item is handwritten.
Number of Image Pages:
2 (105,220 Bytes)
Date:
1956-10-10 (October 10, 1956)
Creator:
Kalckar, Herman M.
National Institutes of Health (U.S.)
Recipient:
Lederberg, Joshua
Rights:
This item is in the public domain. It may be used without permission.
Relation:
Lederberg Grouping: Correspondence C
Box Number: 11
Folder Number: 116
Unique Identifier:
BBAJYF
Accession Number:
16
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1935-2002
SubSeries: 1953-1960
Folder: Kalckar, Herman & Kurahashi, Kiyoshi
Transcript:
Oct 10
Dear Joshua
We hav [sic] not as yet received Morse's comments on Kigoshi's papers; we are otherwise ready to send them to "Science". We have a new lightening test for screening between gal kin-less[?] (gal [ . . .] -- less) and Pgal might[?] trauof[?]-less (4- epemerase-less). The first category is not intub. By having galactose present together with glucose whereas in the latter category the [ . . .] of the two sugars gives a very strong growth inhibition. The exp. Was done partly with the purpose of throwing light on the pathological symplous in Congen. Galactodemia. It is almost evident now that it is gal-1-Pacc and not galactose acc. Which is responsible for the growth inhibition. It could be due to gal-1-P being an enzyme inhibitor and that is to some extent the case. Ginseberg has shown that gal-1-P
[END PAGE ONE]
[BEGIN PAGE TWO]
inhibitor USPG pyro phosphorylase. I believe, however that the growth inhibitation [sic] is rather due to a "bleeding out" of ATP, somewhat like dinitrophenol. Wahla and Kurahash have experiments which support this latter view.
We must have a discussion the 20 or 21
Sincerely Herman
Metadata Last Modified Date:
2009-06-22
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