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The Joshua Lederberg Papers

Letter from Herman M. Kalckar to Joshua and Esther Lederberg pdf (185,171 Bytes) transcript of pdf
Letter from Herman M. Kalckar to Joshua and Esther Lederberg
Item is handwritten.
Number of Image Pages:
2 (185,171 Bytes)
1959-04-22 (April 22, 1959)
Kalckar, Herman M.
National Institutes of Health (U.S.)
Lederberg, Esther
Lederberg, Joshua
This item is in the public domain. It may be used without permission.
Lederberg Grouping: Correspondence C
Box Number: 11
Folder Number: 116
Unique Identifier:
Accession Number:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence, 1935-2002
SubSeries: 1953-1960
Folder: Kalckar, Herman & Kurahashi, Kiyoshi
April 22 59
Dear Josh and Ester [sic],
Here are some additional facts about 3099. It is definitely defect in galkin, Pgal with[?] Transferase and 4-Epimerase (the latter is a complete block). This is the case whether I grow on Min Med with or without galactose or in nutrient medium. Even after 8 hrs additional exposure to 5% galactose there is no 'comeback.' B-galactosidase is also present in galactosefree medium (glycerol, NH3 minerals) although the amounts are a good deal smaller (ca 5-6%) than in the presence of 0.5% galactose. There seems to be no basis for a gal permease block. Glucose-6 phosphate dehydrogenase and UDPG pyrophosphorylase are present. I am set for microgalactose Liter-mediation of the polysaccharides of the various mutants. 3099 should be devoid of galactose.
I should send you a scheme with [LINE DIAGRAM] - because I still cannot remember the origin of gal 9. Please, send me nice charts ([CIRCLE]) just like you were writing a child and also your further plans with Gal 9.
I would be greatly interested in 4-epimerase mutants of Salmonella and Shigella Sonii. Both are very rich in galactose and would presumably change their immunological characteristics (selection in antiserum in gal free medium. Shigella Sonii is attacked by some of the T phages - - perhaps an epimerase-less would also become phage-resistant. This is Aaron Novick's suggestion.
My apologies I was just writing a Danish letter in between. Thanks a lot for the splendid days we spent during the Genetics meeting. Thanks also for writing Boris Rotman. I hope that he will answer me soon since Mike Yarmonlinsky one of Sid Colowick's and Werner Maas's top students again visited me and asserted that he has definitely decided in favor of going with me. I told him now about our correspondence with Rotman and asked him to wait another 10 days. Do you think that Boris would be content with a fellowship? How long time is he going to spend with Bernie Davis and when? Anyhow the Research Assoc. position ($7000, subject to tax) is also with tenure and without staff affiliation. In case he applies for a fellowship I imagine that he should at least $5500. Anyhow if he has can make up his mind soon I may take him for the Research Assoc. position I ought only to be thankful that so many bright young people want to come and work with me. I think, however, that Milton Weiner is too advanced, at least in rank and salary to switch.
Now don't forget these nice drawings! Just like you were writing for 'Endeavor' or "Scientific Monthly."
Kindest regards also from Barbara.
Sincerely Herman
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