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The Joshua Lederberg Papers

Title:
Postcard from James D. Watson to Joshua Lederberg Annotation pdf (31,471 Bytes)
Postcard from James D. Watson to Joshua Lederberg
Description:
Item is handwritten.
Number of Image Pages:
1 (31,471 Bytes)
Date:
1950-01-17 (January 17, 1950)
Creator:
Watson, James D.
Recipient:
Lederberg, Joshua
Rights:
Reproduced with permission of James D. Watson.
Relation:
Lederberg Grouping: Correspondence B
Box Number: 8
Folder Number: 109
Unique Identifier:
BBAMTA
Accession Number:
20
Document Type:
Postcards
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Poor
Series: Correspondence, 1935-2002
SubSeries: 1947-1953
Folder: Watson, James D.
Metadata Last Modified Date:
2005-06-10
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples

Annotation by Joshua Lederberg:
KW: radiation survival of heterozygous diploids; balanced lethals?;
like B/r?; 

provided to JDW this date on his request
jl 7/30/99

-------------------
transcribed 5/6/03:
-------

1-17-50

Dear Josh
     If you irradiate your heterozygotes with uv and pick up
survivors after a heavy dose -- say 10^6 survival , might not
balanced lethals be produced.  They could not segregate so a
stable diploid would be made.  Would its survival curve be like
B/r?
                                           Jim

----
[footnote:  We had been doing such experiments and it turns out
that uv induces segregation and we did get some evidence accordingly
that lethals were not the main mode of inactivation in E. coli.]

5/6/03