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The Joshua Lederberg Papers

Title:
Letter from Edward L. Tatum to Joshua Lederberg Annotation pdf (60,469 Bytes) transcript of pdf
Letter from Edward L. Tatum to Joshua Lederberg
Description:
Item is handwritten.
Number of Image Pages:
1 (60,469 Bytes)
Date:
1946-01-25 (January 25, 1946)
Creator:
Tatum, Edward L.
Recipient:
Lederberg, Joshua
Rights:
Reproduced with permission of Margaret (Tatum) Easter and Barbara Tatum.
Relation:
Lederberg Grouping: Correspondence A
Box Number: 6
Folder Number: 71
Unique Identifier:
BBAPFK
Accession Number:
14
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Fair
Series: Correspondence, 1935-2002
SubSeries: 1925-1947
Folder: Tatum, E. L.
Transcript:
Jan 25 46
Dear Josh:
The idea of picking up deficient mutants is very good, and I'm glad to hear the preliminary results are encouraging. N. Fries used a similar technique (but on minimal agar) for the preliminary screening of Ophiostoma x-ray biochemical mutants -- fairly successfully.
Regarding the effect of time of incubation on appearance of mutations, I think its [sic] still worth doing, even if Demerec has done the equivalent (paper just submitted to PNAS) with x-rayed coli; plated immediately, and sprayed, after incubation 1, 2, 3, 4 etc. [ . . . ], with virus. With both x and u.v. "ray direction [?]" there is a definite lag in appearance of resistant mutants. For biochemicals, incubation would have to be prior to plating.
Dr. Sinnatt assures me that the tower room will be available in March -- rent free -- for the entire term of your stay if you wish.
I'll be in N.Y. this week-end -- and will give you a ring when I have time -- or will leave word with the Ryans. (I just realized you can't get this till Mon.!)
Yours, Ed. T.
Metadata Last Modified Date:
2017-06-21
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Annotation by Joshua Lederberg:
KW: re my methods of enriching for or eyeballing auxotrophic mutants;
=>  P-3; post-treatment incubation (to allow segregation?);  Demerec;
Osborn tower available to me rent-free;

9/11/99