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The Joshua Lederberg Papers
Letter from Joshua Lederberg to Ralph Steinman
Item is handwritten. Item is a photocopy.
Number of Image Pages:
1 (47,482 Bytes)
1988-05-05 (May 5, 1988)
This item is in the public domain. It may be used without permission.
11 & 12
Activation of AIDS: by AZT?
The thought has concerned me for some time that Xray, cytoxic chemicals are good candidates for the activation of a latent virus -- as they do in bacterial prophage . . .
The worse thought arises that AZT might also do just that, albeit it inhibits the replication of the virus as well.
Do you know of any way in which this possibility has been tested -- with animal cells? with lysogenic bacteria?
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Annotation by Joshua Lederberg:
KW: handwritten; could latent HIV be activated by AZT? Compare lysogenic bacteria; jl 10/18/99
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