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The Joshua Lederberg Papers

Title:
Letter from Joshua Lederberg to Attallah Kappas pdf (44,112 Bytes) transcript of pdf
Letter from Joshua Lederberg to Attallah Kappas
Description:
Item is handwritten. Item is a photocopy.
Number of Image Pages:
1 (44,112 Bytes)
Date:
1983-06-09 (June 9, 1983)
Creator:
Lederberg, Joshua
Recipient:
Kappas, Attallah
Rights:
This item is in the public domain. It may be used without permission.
Relation:
Lederberg Grouping: Correspondence E
Box Number: 34
Folder Number: 30
Unique Identifier:
BBAQNC
Accession Number:
81
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1935-2002
SubSeries: 1978-1984
Folder: Kappas, Attallah
Transcript:
6/9/83
Joshua Lederberg
-- Your triplets --
Dear Kap
That's an interesting case; and your hypothesis is certainly plausible. I can see no way to affirm or deny 1 case: a few other hypotheses occur to me.
A) accepting monozygosity
1) Perhaps a virol [sic] or toxic injury to one fetus preceded (and caused) the circulatory difference: a retarded fetus may evoke less than vascular supply.
2) Postnatal stress may be the immediate modifier of the hypothalamic homeostat, whatever the etiology of that stress (dysnutrition . . . )
B) questioning monozygosity
(The data as given are thin. What were the parents' blood groups?)
1) H's failure to thrive reminds one of RUNT runt d[ . . . ]. That is, he may have been a Chimaera with some "graft vs. host" immune reaction [mark to note, or "freemartin" effect]. Chimaeras can be hard to diagnose My colleagues at U. Wis. worked on runting in dizygotic twins in animals. I might be able to dig out some of that literature if it's not already familiar to you.
Thank you for recalling your work of times past.
Joshua.
Metadata Last Modified Date:
2007-01-12
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