[stamped, THE ROCKEFELLER UNIVERSITY OFFICE OF THE PRESIDENT FEB 15 1990]
Dear Dr. Lederberg,
Thank you for the Bardwell review and Craighead reference. I am enclosing a reprint of our paper on asbestos transfection.
Did you see the "editorial" by Brooke Mossman et al. in the Science of Jan 19? (Science 247, 294-301). It has some
seriously misleading statements and implicit assumptions about chrysotile, and I am drafting a response letter now.
We are currently involved in experiments to directly demonstrate insertional mutagenesis mediated by asbestos in rat mesothelium
in vivo. We use a PCR method to amplify up potential insertion sites. The experiments are long ones, and results encouraging
[written in left margin, PNAS 85: 7670 1988]
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[BEGIN PAGE TWO]
but not finished yet. We are also looking at the possibility that the p53 tumor suppressor gene is altered (insertional mutagenesis?)
in the induction of mesothelioma. We shall keep you apprised.