Leaving Chicago, I had the pleasure of Lindegren's company for a long time on a slow I.C. train. In the course of our
conversation, I learned his current views on kappa, and I think that his objections while they are probably unfounded have
not been understood. There is no question as to the role of the cytoplasm in the transmission of kappa, nor that it is present
there in large quantities. However, I agree with him that there is little direct evidence that kappa reproduces itself away
from the gene. His picture of kappa multiplying at the locus of K can only be refuted now by kinetic evidence on the mode
of multiplication of kappa.
In your scheme for enumerating kappa, you presuppose that it is autocatalytic. Have you examined the possibility that at
low levels of kappa the rate of its increase is independent of kappa concentration? I've tried very superficially to
set up the formulae, but have not done more than restate your empirical experiments in the form of recursion formulae:
n number of cell divisions
nn conc. Kappa at the beginning of the n-/1th fission
rn conc. Kappa at the end of the nth fission.
I would like very much to see the mathematical treatment which you referred to in your talk, and to receive your comments
on the matter above. We all, of course, enjoyed your talk very much indeed.