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The Joshua Lederberg Papers

Title:
Letter from Joshua Lederberg to Wilson S. Stone pdf (70,502 Bytes) transcript of pdf
Letter from Joshua Lederberg to Wilson S. Stone
Number of Image Pages:
1 (70,502 Bytes)
Date:
1948-06-28 (June 28, 1948)
Creator:
Lederberg, Joshua
Recipient:
Stone, Wilson S.
Rights:
This item is in the public domain. It may be used without permission.
Relation:
Lederberg Grouping: Correspondence B
Box Number: 8
Folder Number: 73
Unique Identifier:
BBGAPG
Accession Number:
29
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1935-2002
SubSeries: 1947-1953
Folder: Stone, Wilson S.
Transcript:
June 28, 1948.
Dear Dr. Stone,
A culture of Y-87 (B-M-Lac1-V1r) has just been sent off to you. Fortunately, we were able to recover and repurify it. It should behave all right now. If now, a few single-colony streakings on lactose EMB agar will certainly do the trick.
This culture has the interesting faculty of being "mutabile" -- the classical instances of bacterial mutation, namely lactose-positive papillae forming on Lac-EMB agar. Other recurrences of Lac1- have been found which differ in their mutability, and my wife is studying the genetic basis of these differences in mutation rate. So far, they seem to represent asseries of alleles, one might almost say iso-alleles. However, some of the stocks throw off pepiline which are not reverse-mutations, but "suppressor" mutations, i.e. yield Lac-/ which when crossed with the wild type Lac-/ give Lac- recombinants. I thought you might be interested to observe this phenomenon on Lac EMB.
Best regards,
Yours sincerely,
Joshua Lederberg.
Metadata Last Modified Date:
2008-06-10
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