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The Joshua Lederberg Papers

Letter from T. C. Sheng to Joshua Lederberg Annotation pdf (66,426 Bytes) transcript of pdf
Letter from T. C. Sheng to Joshua Lederberg
Item is handwritten.
Number of Image Pages:
1 (66,426 Bytes)
1946-05-13 (May 13, 1946)
Sheng, T. C.
Lederberg, Joshua
Courtesy of Joshua Lederberg.
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Lederberg Grouping: Correspondence A
Box Number: 6
Folder Number: 53
Unique Identifier:
Accession Number:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence, 1935-2002
SubSeries: 1925-1947
Folder: Ryan, Francis J.
May 13, 1946
Dear Dr. Lederberg,
Your letter dated May 8 was duly received. Thank you very much for your valuable suggestions.
We now try to work with leucinless [sic] 3375 and leucineless 8839. We have the idea of killing two birds with the same stone, i.e. we mark the albino vs. wild strains with the two leucinless [sic] genes to ensure a heterocarytic condition for the study of pigment nuclei relationship, and at the time we mark the two leucinless [sic] nuclei with albino and pink color respectively so that a study of the dominance relationship of the two leucinless [sic] (which were found to be non-allelic) is possible.
For the time being, therefore we don't need your cultures 5450-a and 5531-15300a any more, particularly because the heterocaryon of them is colorless instead of pink as expected. However someday we may need it, since as you see any exception in science may be of great value.
Sincerely yours
T.C. Sheng
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Annotation by Joshua Lederberg:
KW: student of C.C. Tan and F J Ryan; nuclear ratio in 
heterokaryons and phenotype; albino, pant, nic markers; requests

jl 6/24/00