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The Joshua Lederberg Papers

Title:
"Program in Molecular Neurobiology" Proposal Annotation pdf (712,629 Bytes) ocr (17,996 Bytes)
"Program in Molecular Neurobiology" Proposal
Description:
Item is a photocopy.
Number of Image Pages:
7 (712,629 Bytes)
Date:
1962-08-30 (August 30, 1962)
Creator:
Lederberg, Joshua
Rights:
This item is in the public domain. It may be used without permission.
Relation:
Lederberg Grouping: No Epoch
Box Number: 5
Folder Number: 35
Unique Identifier:
BBGLBX
Accession Number:
80
Document Type:
Grant proposals
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Academic Career, 1925-1999
SubSeries: Stanford University
SubSubSeries: Department of Genetics
SubSubSubSeries: Courses/Programs
Folder: Program in Molecular Neurobiology, 1962
Metadata Last Modified Date:
2005-03-28
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples

Annotation by Joshua Lederberg:
KW:  This was to have been the centerpiece of the programs sponsored
by the Kennedy Laboratories for Molecular Medicine;  it was funded; I
am seeking more detail about progress reports, and its gradual devolution
to Eric Shooter's studies on NGF - Nerve Growth Factor;  it would be
called "Brain Proteomics" today, and that study still needs to be
implemented, along with comprehensive quests for genetic polymorphisms;

The microscan mass spectrometer is an anticipation of MALDI; alas our
vacuum systems were too clean, and we missed others' inadvertent
discoveries of matrix assistance.  Episequential prtotein modification:
has been vindicated in many other examples of post-translational
modification, e.g methylation of histones;  hunch about glutamine is
probably flawed, but ...,;

N.B.: cf realiation of this strategy in:
AU COMINGS, DE
TI PC1 DUARTE, A COMMON POLYMORPHISM OF A HUMAN-BRAIN PROTEIN, AND
   ITS RELATIONSHIP TO DEPRESSIVE DISEASE AND MULTIPLE-SCLEROSIS
SO NATURE
VL 277: 28 - 32 ; 1979
C1 CITY HOPE NATL MED CTR,DEPT MED GENET,DUARTE,CA 91010
---

Of course, colorblindness must be an instance;

further note 1/26/04: posttranslational deamidation is reported for
cytochrome see CEN 2/17/02  Flatmark


jl 10/29/02   8/04/03  1/26/04