The Transformation In Vitro of R Pneumococci into S Forms of Different Specific Types by the Use of Filtered Pneumococcus
Alloway published this article shortly after he joined Avery's lab. In it, Alloway demonstrated that by dissolving certain
living pneumococci cells in sodium dexoycholate one could bring about transformation in vitro, rather than in laboratory mice
as had previously been demonstrated. Through the process described here, he yielded the first soluble preparation of DNA,
although it was not to be identified as such for 10 more years.
Number of Image Pages:
9 (711,828 Bytes)
1932-01-01 (January 1, 1932)
Alloway, J. Lionel
Periodical: Alloway, J. Lionel. "The Transformation In Vitro of R Pneumococci into S Forms of Different Specific Types by the Use
of Filtered Pneumococcus Extracts." Journal of Experimental Medicine 55, 1 (1 January 1932): 91-99. Article. 9 Images.
Rockefeller University Press
Reproduced with permission of the Rockefeller University Press.
Medical Subject Headings (MeSH):
Shifting Focus: Early Work on Bacterial Transformation, 1928-1940
Beitrage zur Variabilitat der Pneumokokken (1928)
The Interconvertibility of 'R' and 'S' Forms of Pneumococcus (April 1, 1928)
The Transformation of Pneumococcal Types In Vitro (1930)
Further Observations on the Use of Pneumococcus Extracts in Effecting Transformation of Type In Vitro (February 1, 1933)