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The Oswald T. Avery Collection

Title:
Letter from Joshua Lederberg to Thomas D. Brock pdf (270,829 Bytes) transcript of pdf
Letter from Joshua Lederberg to Thomas D. Brock
Description:
Attached is a photocopy of a page from the 1951 Cold Spring Harbor Symposium.
Item is handwritten. Item is a photocopy.
Number of Image Pages:
2 (270,829 Bytes)
Date:
1989-01-08 (January 8, 1989)
Creator:
Lederberg, Joshua
Recipient:
Brock, Thomas D.
Rights:
This item is in the public domain. It may be used without permission.
Subject:
Medical Subject Headings (MeSH):
Transformation, Bacterial
Exhibit Category:
After the Discovery: The Transforming Principle's Reception by the Scientific Community
Box Number: 4
Folder Number: 9
Unique Identifier:
CCAAID
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Commentary on Avery and His Work, 1944-2005
SubSeries: Chronological
Folder: 1980-1994
Transcript:
Jan 8 1989
Dear Tom:
Contributions of pneumococcus to bacterial genetics
Of course Avery et al. 1944 first focused attention on DNA. So it had everything to do with molecular genetics.
But pneumococcus was too difficult to work with.* That motivated search for other systems - esp. Haemophilius and Bacillus, eventually E. coli.
But don't overlook:
Hotchkiss and Marmur ca. 1951 linkage in transformation (followed by Nester-Ganesan-JL 1963 PNAS 49: 61-68 in B. subtilis) that associates linkage with covalent coupling on DNA molecules.
J.
* and so there has been no growing school of pn. research as there has for other systems used in bacterial genetics.
[END PAGE ONE]
[BEGIN PAGE TWO]
Bacterial nuclei
P.S.
There is no logic of connection between models of bacterial conjugation and whether there is an organized nucleus.
With a single "chromosome" the only considerations would be a nuclear membrane, and this disappears during mitosis/meiosis in any event.
(Certainly my thinking!)
My own writings were quite skeptical of the miotic figures claimed by Bisset or Delamator. But I could not disprove mitosis with light microscopy -- esp. if one postulated a single long floppy chromosome barely readable.
Metadata Last Modified Date:
2010-07-16
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