I have now been back from the States one week and have much to tell you but I will begin with the item which needs your active
A rather promising young man, one Dr. Tarr from Montreal, has turned up to work in this Department on problems of bacterial
metabolism. His own wish is to investigate biochemically the difference in two strains of the same organism exhibiting rough
and smooth type colonies especially where such types show a difference in pathogenicity. I suggested to him that it would
be interesting to adopt for the purpose the haemolytic streps associated with puerperal fever in view of the fact that the
M.R. C was inaugurating an attack on this disease, and that therefore material and cooperation might be forthcoming and we
might also hope to gather results which might be of use in characterization of strains. The young man in question fell in
very readily with this proposal; will you let me know if it strikes you as a feasible plan and if so help us to get in touch
with the right bacteriologist to supply us with strains.
I had a marvelous time in America both as regards holiday and work. As regards the latter, on the technical side I worked
first in the Department of Prof. Robert Chambers in Washington Square where I learnt the use of his micro-dissection apparatus
and then T was passed on to Dr. Morton Kahn of Cornell who is an expert in the application of the apparatus to the isolation
of the single bacterial cell. In both these Departments I received an incredible lot of kindness and invaluable help. I
am now engaged in trying to acquire the (rather expensive) apparatus from Leitz.
From Dr. Dakin I got introductions to Avery and Heidelberger and from these I was enabled to get a most valuable insight into
the methods by which chemical problems of immunology are being attacked and a view of the rapidity with which this subject
is advancing over there; in fact I got the idea that along these lines the most significant move in biochemistry is now being
made. The subject is being approached from so many angles by so many workers (al1 quite ready to spend time telling one all
about it) that one finally comes away with a very vivid idea of the lines on which things are progressing.
However I can't tell you all in a letter so I will stop right now.
KW: visited Chambers, Kahn re single cell isolation; Avery Heidelberg
re chemical immunology -- no ref. to transformation; a Dr Tarr interested
in chemistry of Rough/Smooth bacterial colonies;