Letter from Norman H. Horowitz to Joshua Lederberg
In this brief note, Horowitz told Lederberg that he could provide little assistance in Lederberg's quest to determine
the early influences of Avery's ideas. Horowitz suggested that Lederberg contact Bob Sinsheimer.
Number of Image Pages:
1 (45,988 Bytes)
1972-10-30 (October 30, 1972)
Horowitz, Norman H.
Reproduced with permission of Norman H. Horowitz.
After the Discovery: The Transforming Principle's Reception by the Scientific Community
I can't find anything in my old correspondence that would be helpful in connection with the history of Avery's ideas.
I have looked up Beadle's 1945 paper in Chem. Rev., however, and find on page 76 a clear statement that I am sure represents
the views we held at that time. Beadle also refers to Wright's 1945 review in Ann. Rev. Physiol., in which he points
out the great significance of Avery et al.'s discovery. I am sure we would have considered it a very long shot--probably
a waste of time--to attempt to transform a eucaryotic organism, and this without minimizing the importance of Avery's
I mentioned your question to Bob Sinsheimer, and he told me that Avery's paper was what decided him to to into nucleic
acids. This was probably in the early
'50s. You can get more details from him.