Some years ago, I think it was in 1981, I spoke with you about the reception of Avery, MacLeod, and McCarty's discovery
that DNA is the genetic material. At that time you told me about your attempt to duplicate their results using a system involving
Neurospora, and you impressed upon me the fact that their work was certainly not unknown and unrecognized. Last summer, as
I was reading Dr. McCarty's recent book I thought that perhaps I might have another go at the subject.
Historical investigation of this episode in twentieth century biology always seems to have been designed to answer the question
of whether or not the scientific community -- or the Rockefeller team itself -- recognized the significance of that discovery.
(I sometimes think that the reason this question seemed important has nothing to do with the history of science and everything
to do with the fact that Avery did not receive a certain scientific award.) In the first half of the enclosed paper, I try
to prove that there is every reason to believe that the Rockefeller work was widely appreciated as having the genetic significance
our biology textbooks now take for granted.
In the rest of the paper I try to show that in spite of its overwhelming significance it was not immediately clear how to
use the knowledge that genes were made of DNA to initiate further chemical investigations of the gene. I argue that acceptance
of Avery's discovery did not help scientists decide what to do next, and so it did not function as a paradigm in one of
Kuhn's senses. Using a musical metaphor: Avery, MacLeod and McCarty are part of the slow introduction to the mighty symphony
which is molecular genetics.
If in your very busy life you could find the time to glance at this piece of mine, I would be honored. I have also sent a
copy to Dr. McCarty. If you are too tied up with other things I will certainly understand.
I think it was Dr. Johnson who said that praise is the tribute a man is expected to pay for the grant of perusing a manuscript.
I am not writing in hope of exacting the price of praise, but in hope of receiving a smaller sum: criticism.