The Elaboration of Specific Soluble Substance by Pneumococcus During Growth
Dochez and Avery discovered that culture fluids of pneumococci which were filtered to remove bacteria contained a substance
in solution that precipitated when added to certain antisera, and which proved to be type specific. They reasoned that this
component, which they called the "specific soluble substance," or SSS, was released in the body from the masses of
pneumococci in the lungs of pneumonia patients and then excreted from the kidney and therefore present in patients' urine.
Thus, it was possible to diagnose the type of pneumonia with which a person was infected by means of a simple urine test.
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2-3 May 1917
Dochez, A. R.
Avery, Oswald T.
Periodical: Dochez, A. R., and Oswald T. Avery. "The Elaboration of Specific Soluble Substance by Pneumococcus During Growth."
Transactions of the Association of American Physicians 32, ([2-3 May 1917]): 281-298. Article. 18 Images.
Blackwell Scientific Publications
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