Avery's research on the specific soluble substance, or SSS, was an attempt to identify the substance that was responsible
for the specific immunological reactions produced in pneumonia patients. Here, Avery and Heidelberger detailed their efforts
to obtain pure samples of SSS and hypothesized that the substance consisted primarily of carbohydrates, rather than a protein,
which was then believed to be the only substance that could stimulate antibody production. This article was published six
years after an article written with Alphonse Dochez on SSS. The collaboration between Avery and Heidelberger initiated a
line of research that yielded two articles, and after Heidelberger left for Mount Sinai Hospital in 1924, several by Avery
with Walther Goebel and F.H. Babers in the late 1920s.
Item is a photocopy.
Number of Image Pages:
7 (628,171 Bytes)
1923-06 (June 1923)
Avery, Oswald T.
Periodical: Heidelberger, Michael, and Oswald T. Avery. "The Soluble Specific Substance of Pneumococcus." Journal of Experimental
Medicine 38, 1 (June 1923): 73-79. Article. 7 Images.
Rockefeller University Press
Reproduced from The Journal of Experimental Medicine, 1923, vol. 38, pp. 73-79 by copyright permission of The Rockefeller
The "Sugar-Coated Microbe" and the Search for a Cure for Pneumonia, 1919-1929
The Making of an Immunologist: Heidelberger's Years at the Rockefeller Institute, 1912-1927
The Elaboration of Specific Soluble Substance by Pneumococcus During Growth [2-3 May 1917]
Immunologic Relationships of Cell Constituents of Pneumococcus (June 1923)
The Soluble Specific Substance of Pneumococcus: Second Paper (August 1924)
The Soluble Specific Substance of Pneumococcus: Third Paper (October 1925) (in The Michael Heidelberger Papers)
The Soluble Specific Substance of Pneumococcus: IV. On the Nature of the Specific Polysaccharide of Type III Pneumococcus
(November 2, 1926) (in The Michael Heidelberger Papers)
The Soluble Specific Substance of Pneumococcus: V. On the Chemical Nature of the Aldobionic Acid from the Specific Polysaccharide
of Type III Pneumococcus (September 1, 1927) (in The Michael Heidelberger Papers)