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The Oswald T. Avery Collection

Title:
Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: I. The Synthesis of p-Aminophenol beta-Glucoside, p-Aminophenol beta-Galactoside, and Their Coupling with Serum Globulin pdf (854,853 Bytes) ocr (24,501 Bytes)
Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: I. The Synthesis of p-Aminophenol beta-Glucoside, p-Aminophenol beta-Galactoside, and Their Coupling with Serum Globulin
Description:
The first of a long series of studies on efforts by Avery's lab to chemically couple the type-II and type-III pneumonia polysaccharides to protein. Although Avery oversaw most of these experiments, their principle investigator was Goebel, who in 1939, independently demonstrated that the specificity of the type-III polysaccharide is inherent in the structure of the disaccharide, glucose-glucuronic acid. When the disaccharide was coupled with the protein, it yielded a synthetic antigen that induced the formation of antibodies reactive with the intact polysaccharide. These antibodies could protect laboratory animals against type-III infection.
Item is a photocopy.
Number of Image Pages:
11 (854,853 Bytes)
Date:
1929-10 (October 1929)
Creator:
Goebel, Walther F.
Avery, Oswald T.
Source:
Periodical: Goebel, Walther F., and Oswald T. Avery. "Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: I. The Synthesis of p-Aminophenol beta-Glucoside, p-Aminophenol beta-Galactoside, and Their Coupling with Serum Globulin." Journal of Experimental Medicine 50, 4 (October 1929): 521-531. Article. 11 Images.
Publisher:
Rockefeller University Press
Rights:
Reproduced from the Journal of Experimental Medicine, 1929, 50, 521-531, by copyright permission of the Rockefeller University Press.
Exhibit Categories:
The "Sugar-Coated Microbe" and the Search for a Cure for Pneumonia, 1919-1929
Shifting Focus: Early Work on Bacterial Transformation, 1928-1940
Relation:
Metadata Record Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: II. Immunological Specificity of Synthetic Sugar-Protein Antigens (October 1929) pdf (1,383,311 Bytes) ocr (38,415 Bytes)
/ps/access/CCGMCM.pdf
Metadata Record Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: III. Active and Passive Anaphylaxis with Synthetic Sugar-Proteins (November 1929) pdf (1,210,823 Bytes) ocr (31,748 Bytes)
/ps/access/CCGMCN.pdf
Metadata Record Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: IV. The Synthesis of the p-Aminobenzyl Ether of the Soluble Specific Substance of Type III Pneumococcus and Its Coupling with Protein (August 1931) pdf (511,064 Bytes) ocr (14,313 Bytes)
/ps/access/CCGMCP.pdf
Metadata Record Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: V. The Immunological Specificity of an Antigen Prepared by Combining the Capsular Polysaccharide of Type III Pneumococcus with Foreign Protein (August 1931) pdf (849,136 Bytes) ocr (23,137 Bytes)
/ps/access/CCGMCQ.pdf
Metadata Record Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: VI. The Synthesis of p-Aminophenol alpha-Glucoside and Its Coupling with Protein (May 1932) pdf (530,375 Bytes) ocr (14,290 Bytes)
/ps/access/CCGMCR.pdf
Metadata Record Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: VII. Immunological Specificity of Antigens Prepared by Combining alpha- and beta-Glucosides of Glucose with Proteins (May 1932) pdf (990,662 Bytes) ocr (26,207 Bytes)
/ps/access/CCGMCS.pdf
Metadata Record Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: VIII. The Influence of the Acetyl Group on the Specificity of Hexoside-Protein Antigens (July 1934) pdf (754,887 Bytes) ocr (20,727 Bytes)
/ps/access/CCGMCT.pdf
Metadata Record Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: IX. The Specificity of Antigens Prepared by Combining the p-Aminophenol Glycosides of Disaccharides with Protein (November 1934) pdf (1,439,044 Bytes) ocr (38,217 Bytes)
/ps/access/CCGMCV.pdf
Unique Identifier:
CCGMCL
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Folder: [Selected articles collected by NLM]
Metadata Last Modified Date:
2005-04-21
Linked Data:
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