The Occurrence during Acute Infections of a Protein Not Normally Present in the Blood: II. Isolation and Properties of the
After detecting a new protein, the "C-reactive protein," in the serum of pneumonia patients, Avery and T. J. Abernethy
set out to investigate what they believed to be an aspect of the infectious process that transcended the classic antigen-antibody
reactions. Over the course of three papers in 1941, Avery and Abernethy, and later Avery and MacLeod, defined the characteristics
of the protein and established that it was not an antibody. They cited evidence that the protein was instead released from
tissue, likely as a result of cellular damage, and thus was a product of some nonspecific reaction of tissue to injury. Avery
and MacLeod were further able to isolate the C-reactive protein as a highly purified, immunologically homogeneous protein.
Item is a photocopy.
Number of Image Pages:
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1941-02 (February 1941)
MacLeod, Colin M.
Avery, Oswald T.
Periodical: MacLeod, Colin M., and Oswald T. Avery. "The Occurrence during Acute Infections of a Protein Not Normally Present in the
Blood: II. Isolation and Properties of the Reactive Protein." Journal of Experimental Medicine 73, 2 (February 1941):
183-190. Article. 8 Images.
Rockefeller University Press
Reproduced from the Journal of Experimental Medicine, 1941, 73, 183-190, by copyright permission of the Rockefeller University
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