Original Repository: Stanford University Libraries. Department of Special Collections and University Archives. Paul Berg Papers
Reproduced with permission of Gabrielle Crick.
Medical Subject Headings (MeSH):
Protein Synthesis, Tumor Viruses, and Recombinant DNA, 1959-1975
Letter from Francis Crick to Paul Berg (September 18, 1973)
Letter from Paul Berg to Francis Crick (October 18, 1973)
Letter from Francis Crick to Paul Berg (October 25, 1973)
Letter from Paul Berg to Francis Crick (November 5, 1973)
Letter from Francis Crick to Paul Berg (November 8, 1973)
Letter from Francis Crick to Paul Berg (November 28, 1973)
Letter from Paul Berg to Francis Crick (January 3, 1974)
19th October, 1973
I was naturally disappointed not to receive your exciting photos of SV 40
chromatin via the Kornbergs. I understand from Roger that you have said that
both the configurations sketched in my letter of 18th September appear in your
photos. However I cannot easily see how the description of the doughnut given
in your letter to me (undated; received here 5th September) as 100 angstroms thick and "a contour length of 0.1 that of
the free circular DNA" can possibly be correct if the DNA has a molecular weight of 3.4 x 10 [to the sixth] and therefore
a length, naked, of about 17,000 angstroms. Have you shown that the doughnuts contain the full SV 40 DNA? Or does the written
description given in your letter apply to the more extended snake-like forms?
We are still hoping to receive some of your pictures (with dimensions marked
on them) but if you and Griffith feel that you cannot release them at this stage
I would be glad if you would let me know as soon as possible, as in that case we
shall have no choice but to repeat the work independently.