Original Repository: Stanford University Libraries. Department of Special Collections and University Archives. Paul Berg Papers
Reproduced with permission of Gabrielle Crick.
Medical Subject Headings (MeSH):
Protein Synthesis, Tumor Viruses, and Recombinant DNA, 1959-1975
Letter from Paul Berg to Francis Crick (October 18, 1973)
Letter from Francis Crick to Paul Berg (October 19, 1973)
Letter from Paul Berg to Francis Crick (November 5, 1973)
Your letter about the SV40 mini-chromosomes has really whetted our appetite. I
was rather puzzled by your sketch (which looked like [IMAGE] ) whereas Roger tells me the pictures look more like [IMAGE]
and on the other hand I calculate that they should look rather like [IMAGE] !
We would really be most grateful if you could send us a few "typical" pictures, with the scale accurately marked,
so that we could really see for ourselves. Incidentally, what is the contour length of the DNA alone - 1.2[mu]? And where
did you measure the contour length of the doughnut? Was it along the middle of the solid part? How accurate is the figure
I found your description of the dissolution process in high salt rather difficult to visualize (e.g. the "ribbon-like"
appearance, and the spilled-phage look). Could you possibly send us one or two photos of these?
We feel that even though you cannot yet answer all the questions we asked you already have information which would be of great
value to us.
I have just got your letter about Janet Mertz and also a letter from her. I have passed them over to Sydney. I will write
again when I've had a chance to discuss the matter with him.