Original Repository: Stanford University Libraries. Department of Special Collections and University Archives. Paul Berg Papers
Reproduced with permission of Gabrielle Crick.
Medical Subject Headings (MeSH):
Protein Synthesis, Tumor Viruses, and Recombinant DNA, 1959-1975
Letter from Paul Berg to Francis Crick [ca. August 1973]
Roger and I would very much like to know more about the rings of SV 40 DNA covered by histone. What is the contraction ratio?
(I think you said about 10). Are these rings only partly covered by histone, and if so, does the uncovered region have a
variable length or some typical value? If so, what is it?
Are the uncovered bits DNA? And are they single-stranded, double-stranded or 4-stranded? Do the uncovered bits always occur
at the same place on the DNA? etc.
Anything you could tell us would be most gratefully received.
P.S. Do you see any apparently non-circular molecules covered with histone?