Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine


Profiles in Science
   
Pinterest badge Follow Profiles in Science on Pinterest!

The Paul Berg Papers

Title:
Letter from Paul Berg to Robert Langridge pdf (62,887 Bytes) transcript of pdf
Letter from Paul Berg to Robert Langridge
Number of Image Pages:
1 (62,887 Bytes)
Date:
1965-01-11 (January 11, 1965)
Creator:
Berg, Paul
Recipient:
Langridge, Robert
Children's Cancer Research Foundation
Source:
Original Repository: Stanford University Libraries. Department of Special Collections and University Archives. Paul Berg Papers
Rights:
Reproduced with permission of Paul Berg.
Subject:
Medical Subject Headings (MeSH):
RNA
Exhibit Category:
Protein Synthesis, Tumor Viruses, and Recombinant DNA, 1959-1975
Relation:
Metadata Record Letter from Robert Langridge to Paul Berg (January 4, 1965) pdf (57,728 Bytes) transcript of pdf
/ps/access/CDBBDX.pdf
Box Number:
1
Unique Identifier:
CDBBDY
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Transcript:
January 11, 1965
Dear Bob,
Had you been here when I read your letter, you could have helped pick me up off the floor. Although we think have a much improved method for fractionating t-RNA, we have yet to produce any "pure" specific RNA chain. I have estimated that to produce 100 mg of pure t-RNA for your preliminary X-ray work would take approximately 15 gm of starting material and literally thousands of man-hours of work. Consider for example that most t-RNA's represent of the order of less than 5% of the population and even this is a mixture of 3 - 5 different "isomers" of that amino acid-specific class. For the purposes you want, each of these classes has to be separated.
I hope that we can progress to the point where your requirements could considered realistic, but unfortunately at the moment we've not gotten that far.
I relayed your request to Mike for a copy of his paper. My trip to Boston was much too short and I'm sorry I didn't get a chance to talk to you and many of the others I'd hoped to see. The next trip will certainly be for a longer time.
Sincerely,
Paul Berg
Metadata Last Modified Date:
2008-05-01
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples