Chemotherapy of Trypanosome and Spirochete Infections: Chemical Series. I. N-Phenylglycineamide-p-Arsonic Acid
Early twentieth-century scientists had long been attempting to treat trypanosomiasis, or African Sleeping Sickness, with arsenic-based
compounds. Unfortunately, these compounds were largely ineffective and highly toxic. In light of this, Heidelberger and Walter
Jacobs began work to formulate an alternate treatment for the disease. This article describes the pair's successful creation
of a simple, non-toxic, and easily made arsenic compound to treat sleeping sickness, which Simon Flexner, director of the
Rockefeller Institute, named "tryparasamide."
Item is a photocopy.
Number of Image Pages:
5 (393,427 Bytes)
1919-10 (October 1919)
Jacobs, Walter A.
Periodical: Jacobs, Walter A., and Michael Heidelberger. "Chemotherapy of Trypanosome and Spirochete Infections: Chemical Series.
I. N-Phenylglycineamide-p-Arsonic Acid." Journal of Experimental Medicine 30, 5 (October 1919): 411-415. Article. 5 Images.
[Rockefeller Institute for Medical Research]
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Medical Subject Headings (MeSH):
The Making of an Immunologist: Heidelberger's Years at the Rockefeller Institute, 1912-1927