A Method for the Preparation of Crystalline Oxyhemoglobin
In 1921, Heidelberger began to work with Donald D. Van Slyke at the Rockefeller Institute's hospital. Van Slyke had been
working to understand the functioning of the kidneys, and more specifically the interaction between oxygen and hemoglobin.
At this time, oxyhemoglobin (in which an oxygen molecule is attached to the heme component of the hemoglobin protein) could
be produced synthetically in quantities too small to be useful, and also lacked much oxygen-carrying capability. Van Slyke
and his team asked Heidelberger to address this problem. In this article, Heidelberger describes a method he developed that
created greater yields of oxyhemoglobin with nearly all of its oxygen-carrying power intact.
Item is a photocopy.
Number of Image Pages:
10 (764,580 Bytes)
1922-07-01 (July 1, 1922)
Periodical: Heidelberger, Michael. "A Method for the Preparation of Crystalline Oxyhemoglobin." Journal of Biological Chemistry
53, 1 (1 July 1922): 31-40. Article. 10 Images.
[American Society for Biochemistry and Molecular Biology]
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Medical Subject Headings (MeSH):
The Making of an Immunologist: Heidelberger's Years at the Rockefeller Institute, 1912-1927