Immunological Relationships of Cell Constituents of Pneumococcus: Second Paper
In this article, Avery and Heidelberger discuss their findings regarding the immunologic relationship between the nucleoprotein
and carbohydrate portions of pneumococcus. The pair found that the carbohydrate portion of each type of pneumococcus (by
1923 scientists had identified three different types I, II, and III, roughly based on capsule size) was in fact a polysaccharide
unique to that particular type. They also found that while the nucleoprotein component is antigenic when isolated outside
of the cell, the polysaccharide component is not. Heidelberger and Avery concluded that the two combine to form an antigenic
complex that has different properties than each of its member components.
Item is a photocopy.
Number of Image Pages:
10 (805,208 Bytes)
1925-08 (August 1925)
Avery, Oswald T.
Periodical: Avery, Oswald T., and Michael Heidelberger. "Immunological Relationships of Cell Constituents of Pneumococcus: Second
Paper." Journal of Experimental Medicine 42, 3 (August 1925): 367-376. Article. 10 Images.
[Rockefeller Institute for Medical Research]
Reproduced from the Journal of Experimental Medicine, 1925, 42, 367-376 by copyright permission of the Rockefeller University
Medical Subject Headings (MeSH):
The Making of an Immunologist: Heidelberger's Years at the Rockefeller Institute, 1912-1927
The "Sugar-Coated Microbe" and the Search for a Cure for Pneumonia, 1919-1929