Heidelberger's work on the antigenic properties of pneumococcus polysaccharides was met with skepticism at first. Critics
charged that his solutions had been tainted with proteins or protein-like substances, and that these were responsible for
the observed antigenic effect. Heidelberger methodically responded to these charges in articles such as this, in which he
presented the results of many different experiments that showed that the specific antigenic substance was not a protein, but
a structurally unique polysaccharide.
Item is a photocopy.
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Periodical: Heidelberger, Michael. "The Chemical Nature of Immune Substances." Physiological Reviews 7, 1 (1927): 107-128. Article.
[American Physiological Society]
Reproduced with permission of the American Physiological Society.
Medical Subject Headings (MeSH):
Allergy and Immunology
The Making of an Immunologist: Heidelberger's Years at the Rockefeller Institute, 1912-1927