Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine


Profiles in Science
   
Pinterest badge Follow Profiles in Science on Pinterest!

The Michael Heidelberger Papers

Title:
A Quantitative Study of the Precipitin Reaction between Type III Pneumococcus Polysaccharide and Purified Homologous Antibody pdf (1,213,635 Bytes) ocr (34,656 Bytes)
A Quantitative Study of the Precipitin Reaction between Type III Pneumococcus Polysaccharide and Purified Homologous Antibody
Description:
In this article, Heidelberger detailed his findings of what happened when he conducted a precipitin reaction between the polysaccharides of type III pneumococcus and its homologous antibody (an antibody formed against a specific antigen, here type III pneumococcal polysaccharide). Heidelberger demonstrated that when an antigen in solution is exposed to its homologous antibodies, a solid precipitant is formed which can be analyzed by chemical methods to identify its components. Heidelberger developed this so-called precipitin reaction into a powerful experimental method in immunochemistry. It was part of his effort to persuade critics that the polysaccharides, not rogue protein contaminants, were responsible for the antigenic effect he had previously observed.
Item is a photocopy.
Number of Image Pages:
15 (1,213,635 Bytes)
Date:
1929-12 (December 1929)
Creator:
Heidelberger, Michael
Kendall, Forrest E.
Source:
Periodical: Heidelberger, Michael, and Forrest E. Kendall. "A Quantitative Study of the Precipitin Reaction between Type III Pneumococcus Polysaccharide and Purified Homologous Antibody." Journal of Experimental Medicine 50, 6 (December 1929): 809-823. Article. 15 Images.
Publisher:
[Rockefeller Institute for Medical Research]
Rights:
Reproduced from the Journal of Experimental Medicine, 1929, 50, 809-823 by copyright permission of the Rockefeller University Press.
Subject:
Medical Subject Headings (MeSH):
Streptococcus pneumoniae
Antibodies
Pneumococcal Infections
Polysaccharides
Exhibit Category:
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954
Unique Identifier:
DHBBBM
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Folder: [Selected articles collected by NLM]
Metadata Last Modified Date:
2006-05-31
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples