A Quantitative Study of the Precipitin Reaction between Type III Pneumococcus Polysaccharide and Purified Homologous Antibody
In this article, Heidelberger detailed his findings of what happened when he conducted a precipitin reaction between the polysaccharides
of type III pneumococcus and its homologous antibody (an antibody formed against a specific antigen, here type III pneumococcal
polysaccharide). Heidelberger demonstrated that when an antigen in solution is exposed to its homologous antibodies, a solid
precipitant is formed which can be analyzed by chemical methods to identify its components. Heidelberger developed this so-called
precipitin reaction into a powerful experimental method in immunochemistry. It was part of his effort to persuade critics
that the polysaccharides, not rogue protein contaminants, were responsible for the antigenic effect he had previously observed.
Item is a photocopy.
Number of Image Pages:
15 (1,213,635 Bytes)
1929-12 (December 1929)
Kendall, Forrest E.
Periodical: Heidelberger, Michael, and Forrest E. Kendall. "A Quantitative Study of the Precipitin Reaction between Type III Pneumococcus
Polysaccharide and Purified Homologous Antibody." Journal of Experimental Medicine 50, 6 (December 1929): 809-823. Article.
[Rockefeller Institute for Medical Research]
Reproduced from the Journal of Experimental Medicine, 1929, 50, 809-823 by copyright permission of the Rockefeller University
Medical Subject Headings (MeSH):
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954