Quantitative Studies on the Precipitin Reaction: The Role of Multiple Reactive Groups in Antigen-Antibody Union as Illustrated
by an Instance of Cross-Precipitation
In this article, Heidelberger and Kendall gave further evidence that antigens and antibodies were multivalent, meaning that
there was more than one reactive group in each that allowed antigens and antibodies to form two (in the case of antibodies,
as was later shown) or more (in the case of antigens) chemical bonds. This finding was crucial in understanding antigen-antibody
reactions, and ran counter to the assertion by many scientists of the time, including the famous physical chemist Linus Pauling,
that antibodies were univalent.
Item is a photocopy.
Number of Image Pages:
10 (782,892 Bytes)
1934-04 (April 1934)
Kendall, Forrest E.
Periodical: Heidelberger, Michael, and Forrest E. Kendall. "Quantitative Studies on the Precipitin Reaction: The Role of Multiple
Reactive Groups in Antigen-Antibody Union as Illustrated by an Instance of Cross-Precipitation." Journal of Experimental
Medicine 59, 4 (April 1934): 519-528. Article. 10 Images.
[Rockefeller Institute for Medical Research]
Reproduced from the Journal of Experimental Medicine, 1934, 59, 519-528 by copyright permission of the Rockefeller University
Medical Subject Headings (MeSH):
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954