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The Michael Heidelberger Papers

Title:
Quantitative Studies on the Precipitin Reaction: The Role of Multiple Reactive Groups in Antigen-Antibody Union as Illustrated by an Instance of Cross-Precipitation pdf (782,892 Bytes) ocr (21,982 Bytes)
Quantitative Studies on the Precipitin Reaction: The Role of Multiple Reactive Groups in Antigen-Antibody Union as Illustrated by an Instance of Cross-Precipitation
Description:
In this article, Heidelberger and Kendall gave further evidence that antigens and antibodies were multivalent, meaning that there was more than one reactive group in each that allowed antigens and antibodies to form two (in the case of antibodies, as was later shown) or more (in the case of antigens) chemical bonds. This finding was crucial in understanding antigen-antibody reactions, and ran counter to the assertion by many scientists of the time, including the famous physical chemist Linus Pauling, that antibodies were univalent.
Item is a photocopy.
Number of Image Pages:
10 (782,892 Bytes)
Date:
1934-04 (April 1934)
Creator:
Heidelberger, Michael
Kendall, Forrest E.
Source:
Periodical: Heidelberger, Michael, and Forrest E. Kendall. "Quantitative Studies on the Precipitin Reaction: The Role of Multiple Reactive Groups in Antigen-Antibody Union as Illustrated by an Instance of Cross-Precipitation." Journal of Experimental Medicine 59, 4 (April 1934): 519-528. Article. 10 Images.
Publisher:
[Rockefeller Institute for Medical Research]
Rights:
Reproduced from the Journal of Experimental Medicine, 1934, 59, 519-528 by copyright permission of the Rockefeller University Press.
Subject:
Medical Subject Headings (MeSH):
Antigen-Antibody Reactions
Precipitins
Exhibit Category:
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954
Unique Identifier:
DHBBBT
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Folder: [Selected articles collected by NLM]
Metadata Last Modified Date:
2006-06-21
Linked Data:
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