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The Michael Heidelberger Papers

Title:
The Precipitin Reaction between Type III Pneumococcus Polysaccharide and Homologous Antibody: III. A Quantitative Study and a Theory of the Reaction Mechanism pdf (2,277,580 Bytes) ocr (62,186 Bytes)
The Precipitin Reaction between Type III Pneumococcus Polysaccharide and Homologous Antibody: III. A Quantitative Study and a Theory of the Reaction Mechanism
Description:
In this important article, Heidelberger and Kendall presented their quantitative theory of the precipitin reaction, from which they drew the conclusion that both antigens and antibodies were multivalent, meaning that they could form more than one bond with one another. (Scientists subsequently established that antibodies have two binding sites, while antigens can have several dozen.) This was important, as many immunologists of the time argued that antibodies were univalent, that they could bind in only one place to an antigen. Heidelberger and Kendall's findings suggested that antibodies can combine with antigens at widely differing ratios, an essential fact in evaluating the effectiveness of antisera in fighting disease.
Item is a photocopy.
Number of Image Pages:
29 (2,277,580 Bytes)
Date:
1935-04 (April 1935)
Creator:
Heidelberger, Michael
Kendall, Forrest E.
Source:
Periodical: Heidelberger, Michael, and Forrest E. Kendall. "The Precipitin Reaction between Type III Pneumococcus Polysaccharide and Homologous Antibody: III. A Quantitative Study and a Theory of the Reaction Mechanism." Journal of Experimental Medicine 61, 4 (April 1935): 563-591. Article. 29 Images.
Publisher:
[Rockefeller Institute for Medical Research]
Rights:
Reproduced from the Journal of Experimental Medicine, 1935, 4, 563-591 by copyright permission of the Rockefeller University Press.
Subject:
Medical Subject Headings (MeSH):
Antibodies
Streptococcus pneumoniae
Pneumococcal Infections
Polysaccharides
Precipitins
Exhibit Category:
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954
Unique Identifier:
DHBBBW
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Folder: [Selected articles collected by NLM]
Metadata Last Modified Date:
2006-06-01
Linked Data:
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