Chemical Studies on Bacterial Agglutination: II. The Identity of Precipitin and Agglutinin
In this article, Heidelberger and his first graduate student, Elvin A. Kabat, showed that agglutination (the clumping together)
and precipitation of bacterial and other antigens were not triggered by two distinct types of antibodies, as immunologists
had long argued, but were two different functions of the same antibody. Agglutination of bacterial cells, they found, was
a precipitin reaction on the cellular surface, and was subject to the same theory and quantitative analysis.
Item is a photocopy.
Number of Image Pages:
8 (694,086 Bytes)
1936-05 (May 1936)
Kabat, Elvin A.
Periodical: Heidelberger, Michael, and Elvin A. Kabat. "Chemical Studies on Bacterial Agglutination: II. The Identity of Precipitin
and Agglutinin." Journal of Experimental Medicine 63, 5 (May 1936): 737-744. Article. 8 Images.
[Rockefeller Institute for Medical Research]
Reproduced from the Journal of Experimental Medicine, 1936, 63, 737-744 by copyright permission of the Rockefeller University
Medical Subject Headings (MeSH):
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954
Chemical Studies on Bacterial Agglutination: III. A Reaction Mechanism and a Quantitative Theory (June 1937)