Chemical Studies on Bacterial Agglutination: III. A Reaction Mechanism and a Quantitative Theory
In this article, Heidelberger and Kabat continued their work to unravel the chemical processes of bacterial agglutination,
the clumping together of antigen-bearing cells in the presence of antibodies called agglutinins. Here, they laid out a quantitative
theory based on equations derived from the law of mass action that effectively showed that agglutination is analogous to the
precipitin reaction. Their conclusion that agglutinins were not a distinct group of antibodies, but rather that agglutination
and precipitation were separate functions of the same antibodies, overturned established conceptions of the agglutination
process that had placed emphasis on the role of electrolytes and physical force.
Item is a photocopy.
Number of Image Pages:
18 (1,422,939 Bytes)
1937-06 (June 1937)
Kabat, Elvin A.
Periodical: Heidelberger, Michael, and Elvin A. Kabat. "Chemical Studies on Bacterial Agglutination: III. A Reaction Mechanism and
a Quantitative Theory." Journal of Experimental Medicine 65, 6 (June 1937): 885-902. Article. 18 Images.
[Rockefeller Institute for Medical Research]
Reproduced from the Journal of Experimental Medicine, 1937, 65, 885-902 by copyright permission of the Rockefeller University
Medical Subject Headings (MeSH):
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954
Chemical Studies on Bacterial Agglutination: II. The Identity of Precipitin and Agglutinin (May 1936)