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The Michael Heidelberger Papers

Title:
Quantitative Chemical Studies on Complement or Alexin: I. A Method pdf (1,313,965 Bytes) ocr (39,681 Bytes)
Quantitative Chemical Studies on Complement or Alexin: I. A Method
Description:
In the late 1930s, Heidelberger turned to the study of alexin, or immunological complement, blood serum proteins that play an important enzymatic role in regulating immune responses to invading microorganisms, particles, and toxins. Immunologists had puzzled for years over whether or not complement, which at the time was used to refer to the heat-sensitive factor in serum that causes the bursting of antibody-coated cells (immune cytolysis), was a distinct substance, or simply semi-congealed serum. Having determined the molecular weight of polysaccharide-antibody precipitates, Heidelberger was able to show that complement added considerable molecular weight to these precipitates, proving that it was indeed a separate substance. Increased knowledge about alexin would be useful for diagnostic purposes.
Item is a photocopy.
Number of Image Pages:
14 (1,313,965 Bytes)
Date:
1941-06 (June 1941)
Creator:
Heidelberger, Michael
Source:
Periodical: Heidelberger, Michael. "Quantitative Chemical Studies on Complement or Alexin: I. A Method." Journal of Experimental Medicine 73, 6 (June 1941): 681-694. Article. 14 Images.
Publisher:
[Rockefeller Institute for Medical Research]
Rights:
Reproduced from the Journal of Experimental Medicine, 1941, 73, 681-694 by copyright permission of the Rockefeller University Press.
Subject:
Medical Subject Headings (MeSH):
Complement System Proteins
Exhibit Category:
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954
Relation:
Metadata Record Quantitative Chemical Studies on Complement or Alexin: II. The Interrelation of Complement with Antigen-Antibody Compounds and with Sensitized Red Cells (June 1941) pdf (1,433,079 Bytes) ocr (41,507 Bytes)
/ps/access/DHBBCK.pdf
Metadata Record [Lab notes on complement fixation experiments] [October-November 1940] pdf (442,571 Bytes)
/ps/access/DHBBLR.pdf
Unique Identifier:
DHBBCJ
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Folder: [Selected articles collected by NLM]
Metadata Last Modified Date:
2006-06-02
Linked Data:
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