Quantitative Chemical Studies on Complement or Alexin: I. A Method
In the late 1930s, Heidelberger turned to the study of alexin, or immunological complement, blood serum proteins that play
an important enzymatic role in regulating immune responses to invading microorganisms, particles, and toxins. Immunologists
had puzzled for years over whether or not complement, which at the time was used to refer to the heat-sensitive factor in
serum that causes the bursting of antibody-coated cells (immune cytolysis), was a distinct substance, or simply semi-congealed
serum. Having determined the molecular weight of polysaccharide-antibody precipitates, Heidelberger was able to show that
complement added considerable molecular weight to these precipitates, proving that it was indeed a separate substance. Increased
knowledge about alexin would be useful for diagnostic purposes.
Item is a photocopy.
Number of Image Pages:
14 (1,313,965 Bytes)
1941-06 (June 1941)
Periodical: Heidelberger, Michael. "Quantitative Chemical Studies on Complement or Alexin: I. A Method." Journal of Experimental
Medicine 73, 6 (June 1941): 681-694. Article. 14 Images.
[Rockefeller Institute for Medical Research]
Reproduced from the Journal of Experimental Medicine, 1941, 73, 681-694 by copyright permission of the Rockefeller University
Medical Subject Headings (MeSH):
Complement System Proteins
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954
Quantitative Chemical Studies on Complement or Alexin: II. The Interrelation of Complement with Antigen-Antibody Compounds
and with Sensitized Red Cells (June 1941)
[Lab notes on complement fixation experiments] [October-November 1940]