Velocity of Combination of Antibody with Specific Polysaccharides of Pneumococcus
In the early 1940s, Heidelberger turned his attention to studying immunological cross-reactions between type III and type
VIII pneumococcal polysaccharide antigens, respectively, and antibodies formed against the other type of pneumococcal antigen
(meaning that type III pneumococcal antigen reacted with type VIII anti-pneumococcal antibody, and type VIII pneumococcal
antigen with type VIII anti-pneumococcal antibody). Immunological cross reactions occur when antibodies formed against one
antigen react with another antigen that shares identical or closely related binding sites, called immunological determinants,
with the first antigen. From such cross reactions scientists can deduce important details about the chemical composition
of antigens and antibodies. In this paper, Heidelberger and Manfred Mayer reported their findings regarding the speed with
which such cross reactions occurred.
Item is a photocopy.
Number of Image Pages:
8 (789,353 Bytes)
1942-05-01 (May 1, 1942)
Mayer, Manfred M.
Periodical: Mayer, Manfred M., and Michael Heidelberger. "Velocity of Combination of Antibody with Specific Polysaccharides of Pneumococcus."
Journal of Biological Chemistry 143, 3 (1 May 1942): 567-574. Article. 8 Images.
[American Society for Biochemistry and Molecular Biology]
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Medical Subject Headings (MeSH):
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954