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The Michael Heidelberger Papers

Title:
Antibody Formation in Volunteers Following Injection of Pneumococci or Their Type-Specific Polysaccharides pdf (1,652,188 Bytes) ocr (52,393 Bytes)
Antibody Formation in Volunteers Following Injection of Pneumococci or Their Type-Specific Polysaccharides
Description:
During World War II, Heidelberger became involved in an effort by military physicians to develop a pneumonia vaccine, consisting of a combination of purified polysaccharides of four specific pneumococcal types, for the immunization of troops. In this article, Heidelberger and one of his wartime collaborators, Colin MacLeod, along with two coauthors described improvements in their quantitative precipitin method for measuring the amount of type-specific anti-pneumococcal antibodies in human sera, measurements that revealed that an even smaller amount of the specific polysaccharide than used previously was sufficient for effective immunization. Additionally, the team provided data on various injection methods (subcutaneous vs. intracutaneous) and the duration of protection (antibody levels remained relatively constant for 5-8 months after injection).
Item is a photocopy.
Number of Image Pages:
18 (1,652,188 Bytes)
Date:
1946-03 (March 1946)
Creator:
Heidelberger, Michael
MacLeod, Colin M.
Kaiser, Samuel J.
Robinson, Betty
Source:
Periodical: Heidelberger, Michael, Colin M. MacLeod, Samuel J. Kaiser, and Betty Robinson. "Antibody Formation in Volunteers Following Injection of Pneumococci or Their Type-Specific Polysaccharides." Journal of Experimental Medicine 83, 4 (March 1946): 303-320. Article. 18 Images.
Publisher:
[Rockefeller Institute for Medical Research]
Rights:
Reproduced from the Journal of Experimental Medicine, 1946, 83, 303-320 by copyright permission of the Rockefeller University Press.
Subject:
Medical Subject Headings (MeSH):
Pneumococcal Infections
Polysaccharides
Antibodies
Exhibit Category:
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954
Unique Identifier:
DHBBCP
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Folder: [Selected articles collected by NLM]
Metadata Last Modified Date:
2006-06-02
Linked Data:
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