Antibody Formation in Volunteers Following Injection of Pneumococci or Their Type-Specific Polysaccharides
During World War II, Heidelberger became involved in an effort by military physicians to develop a pneumonia vaccine, consisting
of a combination of purified polysaccharides of four specific pneumococcal types, for the immunization of troops. In this
article, Heidelberger and one of his wartime collaborators, Colin MacLeod, along with two coauthors described improvements
in their quantitative precipitin method for measuring the amount of type-specific anti-pneumococcal antibodies in human sera,
measurements that revealed that an even smaller amount of the specific polysaccharide than used previously was sufficient
for effective immunization. Additionally, the team provided data on various injection methods (subcutaneous vs. intracutaneous)
and the duration of protection (antibody levels remained relatively constant for 5-8 months after injection).
Item is a photocopy.
Number of Image Pages:
18 (1,652,188 Bytes)
1946-03 (March 1946)
MacLeod, Colin M.
Kaiser, Samuel J.
Periodical: Heidelberger, Michael, Colin M. MacLeod, Samuel J. Kaiser, and Betty Robinson. "Antibody Formation in Volunteers Following
Injection of Pneumococci or Their Type-Specific Polysaccharides." Journal of Experimental Medicine 83, 4 (March 1946):
303-320. Article. 18 Images.
[Rockefeller Institute for Medical Research]
Reproduced from the Journal of Experimental Medicine, 1946, 83, 303-320 by copyright permission of the Rockefeller University
Medical Subject Headings (MeSH):
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954