The Human Antibody Response to Simultaneous Injection of Six Specific Polysaccharides of Pneumococcus
During World War II, Heidelberger became involved in an effort by military physicians to develop a pneumonia vaccine, consisting
of a combination of purified polysaccharides of four specific pneumococcal types, for the immunization of troops. For this
article, Heidelberger and one of his wartime collaborators, Colin MacLeod, along with M. M. Di Lapi, studied how the body
reacted if injected with more than four types of specific polysaccharides (a combination of four types were administered during
the military field trial) at one time, namely with specific polysaccharides of the six most common types of pneumonia. The
authors found that such a vaccine was as effective as one made of four pneumococcal polysaccharide antigens in stimulating
an immune response.
Item is a photocopy.
Number of Image Pages:
4 (260,676 Bytes)
1948-09 (September 1948)
MacLeod, Colin M.
Di Lapi, Marie M.
Periodical: Heidelberger, Michael, Colin M. MacLeod, and Marie M. Di Lapi. "The Human Antibody Response to Simultaneous Injection
of Six Specific Polysaccharides of Pneumococcus." Journal of Experimental Medicine 88, 3 (September 1948): 369-372. Article.
[Rockefeller Institute for Medical Research]
Reproduced from the Journal of Experimental Medicine, 1948, 88, 369-372 by copyright permission of the Rockefeller University
Medical Subject Headings (MeSH):
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954