Letter from Michael Heidelberger to the Bache Fund
In this grant application Heidelberger highlights the importance of the refrigerated centrifuge to the daily work of a microbiological
laboratory. Heidelberger first proposed a design for a centrifuge with an insulated brine coil around it for cooling when
he was working to produce large quantities of purified oxyhemoglobin at Rockefeller Institute in the early 1920s, a process
during which the surrounding temperature had to be carefully controlled.
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1937-02-18 (February 18, 1937)
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Medical Subject Headings (MeSH):
The Making of an Immunologist: Heidelberger's Years at the Rockefeller Institute, 1912-1927
I should be very happy to be awarded a grant from your Fund for the purchase of a new refrigerated centrifuge, an instrument
which was first built at my suggestion in order to facilitate the preparation of oxyhemoglobin in its active state. The instrument
we have now is becoming unfit for the heavy strain upon it, having been in almost daily use for many hours over a period of
nine years. It has been indispensible for this laboratory's work on absolute methods of immunological analysis, the mechanism
of immune reactions, the isolation of bacterial proteins and polysaccharides, the preparation of immune sera and the isolation
of highly purified antibodies and in studies of the thyroid hormone.
One of the new and improved machines will greatly aid in continuing and facilitating the laboratory's work along these
and other lines. The grant would also be of value to the Department of Bacteriology of the College of Physicians and Surgeons,
Columbia University, for I should give the old machine to that department, where it would still be suitable for the intermittent,
light-duty service to which it would be put.
The total cost of the centrifuge and the necessary accessories is . Should this appear excessive, I should be most grateful
for as large a fraction of this sum as seems fitting.