Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine


Profiles in Science
   
Pinterest badge Follow Profiles in Science on Pinterest!

The Michael Heidelberger Papers

Title:
Induction of Primary and Inhibition of Secondary Antibody Response to Hapten by Hapten Conjugates of Type III Pneumococcal Polysaccharide pdf (844,013 Bytes) ocr (40,387 Bytes)
Induction of Primary and Inhibition of Secondary Antibody Response to Hapten by Hapten Conjugates of Type III Pneumococcal Polysaccharide
Description:
Heidelberger continued his detailed chemical studies of polysaccharide antigens after he returned to New York City and joined the Department of Pathology at the New York University School of Medicine as adjunct professor in 1964. In this article, Heidelberger and his coauthors examined the immunological effects of haptens, small molecules that are not antigenic by themselves but that can elicit the formation of antibodies of appropriate specificity and react with such antibodies when chemically fused, or conjugated, to a larger antigenic molecule, here pneumococcal polysaccharide. In particular, the article compared the effects of conjugated haptens on the primary antibody response--the initial immune response to an antigen--with their effects on the secondary antibody response, in which the level of immunity acquired during the first response (immunity that persists for a variable period of time) normally is boosted by renewed exposure to the same antigenic agent.
Haptens were given their name (from the Greek haptein, to fasten) and their role in immunology was first studied by Karl Landsteiner, with whom Heidelberger collaborated during the early 1920s at the Rockefeller Institute.
Item is a photocopy.
Number of Image Pages:
15 (844,013 Bytes)
Date:
1975-02 (February 1975)
Creator:
Lerman, S. P.
Romano, T. J.
Mond, J. J.
Heidelberger, Michael
Thorbecke, G. J.
Source:
Periodical: Lerman, S. P., T. J. Romano, J. J. Mond, Michael Heidelberger, and G. J. Thorbecke. "Induction of Primary and Inhibition of Secondary Antibody Response to Hapten by Hapten Conjugates of Type III Pneumococcal Polysaccharide." Cellular Immunology 15, 2 (February 1975): 321-335. Article. 15 Images.
Publisher:
Academic Press
Rights:
Reprinted from Cellular Immunology, Vol. 15, Lerman, S. P., T. J. Romano, J. J. Mond, Michael Heidelberger, and G. J. Thorbecke, "Induction of Primary and Inhibition of Secondary Antibody Response to Hapten by Hapten Conjugates of Type III Pneumococcal Polysaccharide," pp. 321-325, Copyright 1975 with permission from Elsevier.
URL: http://www.sciencedirect.com/Exit
   Disclaimer; please review our Privacy Policy
Subject:
Medical Subject Headings (MeSH):
Antibodies
Haptens
Polysaccharides
Exhibit Category:
"If I Have a Few More Years to Work, I'm Going Ahead": An Active Retirement, 1954-1991
Unique Identifier:
DHBBKW
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Folder: [Selected articles collected by NLM]
Metadata Last Modified Date:
2009-03-19
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples